| Identification | Back Directory | [Name]
sodium 4,6-dichloro-3-[(E)-(2-oxo-1-phenyl-pyrrolidin-3-ylidene)methyl]-1H-indole-2-carboxylate | [CAS]
166974-23-8 | [Synonyms]
sodium 4,6-dichloro-3-[(E)-(2-oxo-1-phenyl-pyrrolidin-3-ylidene)methyl]-1H-indole-2-carboxylate | [Molecular Formula]
C20H13Cl2N2NaO3 | [MDL Number]
MFCD00939240 | [MOL File]
166974-23-8.mol | [Molecular Weight]
425.24 |
| Hazard Information | Back Directory | [Uses]
GV-196771A is the sodium salt form of GV196771, is an NMDA receptor antagonist. | [in vivo]
GV196771 is a potent antagonist of the modulatory glycine site of the N-methyl-D-aspartate receptor. GV196771 is a potent antagonist of the modulatory glycine site of the NMDA receptor developed for treatment of neuropathic pain. GV196771 is an NMDA receptor antagonist with low oral bioavailability in rats and mice. GV196771 has low oral bioavailability (<10%) and plasma clearance (~2 mL/min/kg) in rats[1]. | [IC 50]
NMDA Receptor | [storage]
Store at -20°C | [References]
[1] Polli JW, et al. The systemic exposure of an N-methyl-D-aspartate receptor antagonist is limited in mice by the P-glycoprotein and breast cancer resistance protein efflux transporters. Drug Metab Dispos. 2004 Jul;32(7):722-6. DOI:10.1124/dmd.32.7.722 |
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