| Identification | Back Directory | [Name]
2-bromophenylhydrazine | [CAS]
16732-66-4 | [Synonyms]
1-bromo-1-phenylhydrazine
1-(2-Bromophenyl)hydrazine
Hydrazine, (2-bromophenyl)- | [EINECS(EC#)]
240-797-4 | [Molecular Formula]
C6H7BrN2 | [MDL Number]
MFCD00044518 | [MOL File]
16732-66-4.mol | [Molecular Weight]
187.04 |
| Chemical Properties | Back Directory | [Melting point ]
46-48 °C | [Boiling point ]
275.7±23.0 °C(Predicted) | [density ]
1.666±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
4.59±0.10(Predicted) | [Appearance]
Yellow to brown Solid |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of toluene and 2-bromophenylhydrazine from 2-bromotoluene was as follows: in an 8 mL screw-capped test tube, the indicated amounts of CuBr, ligand, phase transfer catalyst (PTC), and 50 mg of water were mixed well. Subsequently, 1 mmol of aryl halide and 10 mol% of the indicated amount of base were added, and the resulting mixture was stirred at a set temperature (bath temperature) for 10 min. Next, the remaining amount of base and the specified amount of hydrazine hydrate (N2H4-H2O) were added. The reaction mixture was continued to be stirred in a closed test tube at the same temperature for 1 hour. After completion of the reaction, it was cooled to room temperature and extracted with 5 mL of ethyl acetate (EtOAc). A 0.1 to 0.2 mL sample of the organic phase was dried over anhydrous sodium sulfate (Na2SO4) and analyzed by gas chromatography (GC). | [References]
[1] Tetrahedron, 2014, vol. 70, # 26, p. 4043 - 4048 |
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