| Identification | Back Directory | [Name]
(3R,4S,5S,6R,7R,9R,11R,12R,13R,14R)-4-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6 -dimethyl-oxan-2-yl]oxy-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-m ethyl-oxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexameth yl-1-oxacyclotetradecane-2,10-dione | [CAS]
1675-02-1 | [Synonyms]
Erythromycin C - API
Erythromycin Impurity 6
Erythromycin Impurity 14
3'-O-Demethylerythromycin
Erythromycin C (E1320000)
3"-O-DeMethylerythroMycin A
Erythromycin, 3''-O-demethyl-
Erythromycin C (Erythromycin Impurity 3)
(3R,4S,5S,6R,7R,9R,11R,12R,13R,14R)-4-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyl-oxan-2-yl]oxy-6-[(2S,3R,4S,6R)-4-dimethylaChemicalbookmino-3-hydroxy-6-methyl-oxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-
(3R,4S,5S,6R,7R,9R,11R,12R,13R,14R)-4-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6 -dimethyl-oxan-2-yl]oxy-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-m ethyl-oxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexameth yl-1-oxacyclotetradecane-2,10-dione
Erythromycin C/(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-(((2R,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexa | [Molecular Formula]
C36H65NO13 | [MDL Number]
MFCD22666225 | [MOL File]
1675-02-1.mol | [Molecular Weight]
719.9 |
| Chemical Properties | Back Directory | [Melting point ]
121-125 °C | [Boiling point ]
826.2±65.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble; Water: limited solubility | [form ]
neat | [pka]
13.09±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Erythromycin C is an intermediate in the biosynthesis of erythromycin . It is also a potential impurity found in commercial preparations of erythromycin. Erythromycin C is half as active or less than erythromycin A or B against most Gram-positive and Gram-negative bacteria tested. | [Uses]
Erythromycin (E649950) impurity. A related substance in Erythromycin drug. | [Uses]
Erythromycin C (3’’-O-demethylerythromycin A) is a minor co-metabolite of erythromycin produced by Saccharopolyspora erythreae. Erythromycin C exhibits a narrower spectrum of antibiotic activity and is much less active than erythromycins A and B. | [Definition]
ChEBI: Erythromycin C is an erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively. It is functionally related to an erythronolide A. It is a conjugate base of an erythromycin C(1+). | [References]
[1] YUN CHEN. Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation.[J]. Applied and Environmental Microbiology, 2008, 74 6: 1820-1828. DOI: 10.1128/aem.02770-07
[2] I O KIBWAGE. Antibacterial activities of erythromycins A, B, C, and D and some of their derivatives.[J]. Antimicrobial Agents and Chemotherapy, 1985, 28 5: 630-633. DOI: 10.1128/aac.28.5.630 |
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