| Identification | Back Directory | [Name]
BMS-200 | [CAS]
1675203-82-3 | [Synonyms]
BMS-200
Butanoic acid, 4-[[[4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]-2,5-difluorophenyl]methyl]amino]-3-hydroxy-, (3S)- | [Molecular Formula]
C27H27F2NO6 | [MOL File]
1675203-82-3.mol | [Molecular Weight]
499.5 |
| Hazard Information | Back Directory | [Description]
BMS-200 is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 80 nM. | [Uses]
BMS-200 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 80 nM. BMS-200 can induce dimerization of PD-L1[1]. | [References]
[1] Katarzyna Guzik, et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867. DOI:10.1021/acs.jmedchem.7b00293 |
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