| Identification | Back Directory | [Name]
PD-L1 inhibitor 1 | [CAS]
1675203-84-5 | [Synonyms]
BMS-202
CS-2416
PD1 inhibitor 2
PD-1 inhibitor 2
PD 1 inhibitor 2
PD-L1 inhibitor 2
PD-L1 inhibitor 1
PD1-PDL1 inhibitor 2
PD-1/PD-L1 inhibitor 2(BMS-202)
BMS202 (PD-1/PD-L1 inhibitor 2)
PD1 INHIBITOR 2;PD 1 INHIBITOR 2;BMS202;BMS 202
PD-L1 INHIBITOR 2;PD-1 INHIBITOR 2;PD1 INHIBITOR 2;PD 1 INHIBITOR 2;BMS 202;BMS202
N-{2-[({2-methoxy-6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)amino]ethyl}acetamide
N-[2-[[[2-Methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]acetamide
Acetamide, N-[2-[[[2-methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]- | [Molecular Formula]
C25H29N3O3 | [MDL Number]
MFCD29905455 | [MOL File]
1675203-84-5.mol | [Molecular Weight]
419.52 |
| Chemical Properties | Back Directory | [Boiling point ]
611.4±55.0 °C(Predicted) | [density ]
1.133±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml) | [form ]
solid | [pka]
16.06±0.46(Predicted) | [color ]
White | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis.1 PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM.2 | [Uses]
BMS-202 is a Novel inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface. | [in vivo]
BMS-202 (20 mg/kg; intraperitoneal injection; daily; for 9 days; NOG-dKO mice) treatment shows a clear antitumor effect compared with the controls, in humanized MHC- dKO NOG mice[2]. | Animal Model: | NOG-dKO mice (8-week-old) injected with SCC-3 cells[2] | | Dosage: | 20 mg/kg | | Administration: | Intraperitoneal injection; daily; for 9 days | | Result: | Showed 41% growth inhibitory activity against humanized mouse-transplanted human lymphoma SCC-3 cells.
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| [storage]
Store at -20°C | [References]
1) Zak?et al.?(2016),?Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1);?Oncotarget?7?30323
2) Guzik?et al.?(2017),?Small-molecule inhibitors of the programmed cell death -1/programmed cell death -ligand 1(PD-1/PD-L1) interaction via transiently induced protein states and dimerization of PD-L1;?J. Med. Chem.?60?5857 |
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