| Identification | Back Directory | [Name]
2-Pyridinecarboxamide, N-[4-[5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl]-3-methylphenyl]- | [CAS]
1678501-16-0 | [Synonyms]
mGlu4 receptor agonist 1
2-Pyridinecarboxamide, N-[4-[5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl]-3-methylphenyl]- | [Molecular Formula]
C21H15ClN4O2 | [MOL File]
1678501-16-0.mol | [Molecular Weight]
390.82 |
| Hazard Information | Back Directory | [Uses]
mGlu4 receptor agonist 1 (compound 62) is a potent mGlu4 receptor positive allosteric modulator, with an EC50 of 308 nM. mGlu4 receptor agonist 1 shows significant anxiolytic- and antipsychotic-like effect[1]. | [IC 50]
mGluR4: 308 ± 35 nM (EC50) | [References]
[1] Stankiewicz A, et al. New 1,2,4-oxadiazole derivatives with positive mGlu4 receptor modulation activity and antipsychotic-like properties. J Enzyme Inhib Med Chem. 2022 Dec;37(1):211-225. DOI:10.1080/14756366.2021.1998022 |
|
|