| Identification | Back Directory | [Name]
cis-Miyabenol C | [CAS]
168037-22-7 | [Synonyms]
cis-Miyabenol C
(2S,2'R,3S,3'R)-3'-(3,5-Dihydroxyphenyl)-2,2',3,3'-tetrahydro-2,2'-bis(4-hydroxyphenyl)-4-[(1Z)-2-(4-hydroxyphenyl)ethenyl]-[3,4'-bibenzofuran]-6,6'-diol
[3,4'-Bibenzofuran]-6,6'-diol,3'-(3,5-dihydroxyphenyl)-2,2',3,3'-tetrahydro-2,2'-bis(4-hydroxyphenyl)-4-[(1Z)-2-(4-hydroxyphenyl)ethenyl]-, (2S,2'R,3S,3'R)-
[3,4'-Bibenzofuran]-6,6'-diol, 3'-(3,5-dihydroxyphenyl)-2,2',3,3'-tetrahydro-2,2'-bis(4-hydroxyphenyl)-4-[(1Z)-2-(4-hydroxyphenyl)ethenyl]-, (2S,2'R,3S,3'R)- (9CI) | [Molecular Formula]
C42H32O9 | [MOL File]
168037-22-7.mol | [Molecular Weight]
680.7 |
| Chemical Properties | Back Directory | [Boiling point ]
886.4±65.0 °C(Predicted) | [density ]
1.484±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
9.25±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
cis-Miyabenol C is an isomer of the resveratrol trimer Miyabenol C, which can be isolated from grape herbs. Miyabenol C is an inhibitor of β-amyloid (Aβ) and amyloid β precursor protein (APP) in Alzheimer's disease model mice, and inhibit β-secretase activity without changing the protein level of β-secretase BACE1[1][2]. | [Definition]
ChEBI:5-{6-hydroxy-4-[6-hydroxy-2-(4-hydroxyphenyl)-4-[2-(4-hydroxyphenyl)ethenyl]-2,3-dihydro-1-benzofuran-3-yl]-2-(4-hydroxyphenyl)-2,3-dihydro-1-benzofuran-3-yl}benzene-1,3-diol is a member of benzofurans. | [References]
[1] Hu J, et al. The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation. PLoS One. 2015 Jan 28;10(1):e0115973. DOI:10.1371/journal.pone.0115973 |
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