| Identification | Back Directory | [Name]
(7(8)-DiHDPA | [CAS]
168111-93-1 | [Synonyms]
(7(8)-DiHDPA
7,8-dihydroxydocosa-4(Z),10(Z),13(Z),16(Z),19(Z)-pentaenoic acid
7,8-Dihydroxy-4(Z),10(Z),13(Z),16(Z),19(Z)-Docosapentaenoic acid | [Molecular Formula]
C22H34O4 | [MOL File]
168111-93-1.mol | [Molecular Weight]
362.51 |
| Chemical Properties | Back Directory | [Boiling point ]
537.8±50.0 °C(Predicted) | [density ]
1.035±0.06 g/cm3(Predicted) | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.25 mg/ml | [pka]
4.58±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
(±)7(8)-DiHDPA is a major metabolite of docosahexaenoic acid (DHA; ) that is produced via oxidation by cytochrome P450 epoxygenases.1 Epoxygenase metabolites of DHA, including (±)7(8)-DiHDPA, suppress aggregation and thromboxane synthesis in isolated platelets.2 | [Uses]
(±)7(8)-DiHDPA is a epoxygenase metabolite of docosahexaenoic acid (HY-B2167). (±)7(8)-DiHDPA inhibits platelet aggregation at concentrations below those affecting thromboxane synthesis[1]. | [Definition]
ChEBI: 7,8-DiHDPE is a very long-chain fatty acid. | [References]
1. VanRollins, M., Baker, R.C., Sprecher, H., et al. Oxidation of docosahexaenoic acid by rat liver microsomes J. Biol. Chem. 259(9),5776-5783(1984).
2. VanRollins, M. Epoxygenase metabolites of docosahexaenoic and eicosapentaenoic acids inhibit platelet aggregation at concentrations below those affecting thromboxane synthesis J. Pharmacol. Exp. Ther. 274(2),798-804(1995). |
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