| Identification | Back Directory | [Name]
L-Alanine, 3-[[[5-[2-(4-piperidinyl)ethyl]thieno[2,3-b]thien-2-yl]carbonyl]amino]-N-(3-pyridinylsulfonyl)- | [CAS]
168157-33-3 | [Synonyms]
L-739758
L-Alanine, 3-[[[5-[2-(4-piperidinyl)ethyl]thieno[2,3-b]thien-2-yl]carbonyl]amino]-N-(3-pyridinylsulfonyl)- | [Molecular Formula]
C22H26N4O5S3 | [MOL File]
168157-33-3.mol | [Molecular Weight]
522.66 |
| Hazard Information | Back Directory | [Uses]
L-739758 is an antagonist for αIIbβ3 integrin (platelet glycoprotein IIb/IIIa). L-739758 acts as a peptidomimetic, binds to αIIbβ3 integrin by mimicking the interaction of the RGD (arginine-glycine-aspartic acid) motif, and is involved in the blood coagulation process. L-739758 inhibits platelet aggregation, and is used for thrombosis research[1]. | [References]
[1] Kóňa J. Comparative study of interaction energies between α IIb β 3 integrin and the peptidic, peptidomimetic and non-peptidic ligands by quantum mechanics FMO-PIEDA calculations[J]. Chemical Papers, 2023, 77(10): 5913-5930. |
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