| Identification | Back Directory | [Name]
N1-1-Naphthalenyl-N2-[7-[[1-[2-(4-quinolinylamino)ethyl]-4-piperidinyl]methoxy]-4-quinazolinyl]-1,2-ethanediamine | [CAS]
1683516-27-9 | [Synonyms]
DNMT-IN-3
N1-1-Naphthalenyl-N2-[7-[[1-[2-(4-quinolinylamino)ethyl]-4-piperidinyl]methoxy]-4-quinazolinyl]-1,2-ethanediamine | [Molecular Formula]
C37H39N7O | [MOL File]
1683516-27-9.mol | [Molecular Weight]
597.75 |
| Chemical Properties | Back Directory | [Boiling point ]
855.9±65.0 °C(Predicted) | [density ]
1.271±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
8.51±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
DNMT-IN-3 is an DNA Methyltransferase (DNMT) inhibitor, and plays an antimalarial role with IC50 of 60 nM against Plasmodium falciparum (Plasmodium). DNMT-IN-3 can be used for malaria related research[1]. | [IC 50]
Plasmodium | [References]
[1] Dobrescu I, et.al. Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors. ACS Infect Dis. 2023 Jun 9; 9(6):1257-1266. DOI:10.1021/acsinfecdis.3c00127 |
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