| Identification | Back Directory | [Name]
COMPOUND 401 | [CAS]
168425-64-7 | [Synonyms]
CS-315
Morpholino a
Compound 401, >=98%
COMPOUND401;COMPOUND-401
2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one
2-(Morpholin-4-yl)pyrimido[2,1-a]isoquinolin-4-one
2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one>
2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one
4H-PyriMido[2,1-a]isoquinolin-4-one, 2-(4-Morpholinyl)-
2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one | [Molecular Formula]
C16H15N3O2 | [MDL Number]
MFCD10568147 | [MOL File]
168425-64-7.mol | [Molecular Weight]
281.314 |
| Chemical Properties | Back Directory | [Melting point ]
184-186℃ (ethanol ) | [Boiling point ]
456.9±55.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Store at RT | [solubility ]
DMSO : 6 mg/mL (21.33 mM; Need ultrasonic and warming) | [form ]
powder to crystal | [pka]
1.01±0.20(Predicted) | [color ]
White to Light yellow | [CAS DataBase Reference]
168425-64-7 |
| Hazard Information | Back Directory | [Uses]
Compound 401 is a selective inhibitor of DNA-PK and FRAP. | [Biological Activity]
Reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC 50 values are 0.28 and 5.3 μ M respectively). Displays little affinity for other commonly studied kinases including PI 3-K, ATM and ATR (IC 50 values are all > 100 μ M). Induces apoptosis in vitro . | [IC 50]
DNA-PK: 0.28 μM (IC50); mTOR: 5.3 μM (IC50) | [storage]
Store at RT |
|
|