| Identification | Back Directory | [Name]
Ethanone, 1-(2'-acetyl-2,3',6,6'-tetrahydroxy[1,1'-biphenyl]-3-yl)- | [CAS]
168706-29-4 | [Synonyms]
1,1’-(2’,3,6,6’-Tetrahydroxy-[1,1’-biphenyl]-2,3’-diyl)diethanone
Ethanone, 1-(2'-acetyl-2,3',6,6'-tetrahydroxy[1,1'-biphenyl]-3-yl)- | [Molecular Formula]
C16H14O6 | [MOL File]
168706-29-4.mol | [Molecular Weight]
302.28 |
| Chemical Properties | Back Directory | [Melting point ]
228 °C (decomp) | [Boiling point ]
614.0±55.0 °C(Predicted) | [density ]
1.429±0.06 g/cm3(Predicted) | [storage temp. ]
-10 to -25°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
7.04±0.48(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
Cynandione A is an acetophenone that can be isolated from Cynanchum Wilfordii Radix. Cynandione A protects hepatocytes and cortical neurons from toxicity and improves neurological deficits in a rat model of cerebral ischemia. On the other hand, cynandione A has significant anti-inflammatory effects and inhibits inflammation by activating macrophage α7 nAChR and IL-10 expression[1]. | [Biological Activity]
Cynandione A is a primary bioactive component of medical plant Cynanchum wilfordii th at exhibit neuroprotective and hepatoprotective effects. Cynandione A induces SIRT1 (silent information regulator 2 homolog 1) nuclear translocation through the PKA signaling pathway resulting in beiging (differentiation) in 3T3-L1 cells. | [References]
[1] Han Q Q, et al. Cynandione A and PHA-543613 inhibit inflammation and stimulate macrophageal IL-10 expression following α7 nAChR activation[J]. Biochemical Pharmacology, 2021, 190: 114600. DOI:10.1016/j.bcp.2021.114600 |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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