| Identification | Back Directory | [Name]
ISOFAGOMINE, HYDROCHLORIDE | [CAS]
169105-89-9 | [Synonyms]
Afegostat
D-Isofagomine
Unii-G23ap190ys
IsofagomineHydrochlroide
ISOFAGOMINE, HYDROCHLORIDE
5-Hydroxymethyl-3,4-piperidinediol
(3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol
3,4-Piperidinediol, 5-(hydroxymethyl)-, (3R,4R,5R)-
(3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol,HCl
(3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol hydrochloride
(3R,4R,5R)-5-(HYDROXYMETHYL)-3,4-PIPERIDINEDIOL, HYDROCHLORIDE | [Molecular Formula]
C6H14ClNO3 | [MDL Number]
MFCD00942569 | [MOL File]
169105-89-9.mol | [Molecular Weight]
183.63 |
| Chemical Properties | Back Directory | [Appearance]
Yellow Low-Melting Solid | [Boiling point ]
317.2±37.0 °C(Predicted) | [density ]
1.279±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [solubility ]
Soluble in DMSO | [form ]
Oil | [pka]
14.19±0.60(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Low-Melting Solid | [Uses]
A selective and very strong inhibitor of ?Glucosidase (Ki0.11uM) | [Definition]
ChEBI: Afegostat is a member of piperidines. | [in vivo]
Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates[1]. | [storage]
Store at -20°C |
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