| Identification | Back Directory | [Name]
AC-DEVD-AMC | [CAS]
169332-61-0 | [Synonyms]
Ac-Devd
AC-DEVD-AMC
AC-DEVD-MCA
AC-DMQD-AMC
ACETYL-DEVD-AMC
AC-DEVD-AMC USP/EP/BP
AC-ASP-GLU-VAL-ASP-AMC
AC-ASP-MET-GLN-ASP-AMC
AC-ASP-GLU-VAL-ASP-MCA
AC-DEVD-AMC AMMONIUM SALT
CASPASE-3 FLUOROGENIC SUBSTRATE
CASPASE-3 SUBSTRATE (FLUOROGENIC)
CASPASE-3 SUBSTRATE II, FLUOROGENIC
AC-ASP-MET-GLN-ASP-AMC: AC-DMQD-AMC
CASPASE 3 SUBSTRATE 1M, FLUOROGENIC
AC-ASP-GLU-VAL-ASP-AMC AMMONIUM SALT
CASPASE-3/CPP32 FLUOROGENIC SUBSTRATE
APOPAIN SUBSTRATE ;AC-ASP-GLU-VAL-ASP-AMC
AC-ASP-GLU-VAL-ASP-7-AMINO-4-METHYLCOUMARIN
AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN
CASPASE 3 (APOPAIN) SUBSTRATE 1M, FLUOROGENIC
Caspase 3 Substrate 1m (Apopain), fluorogenic
ACETYL-ASP-GLU-VAL-ASP-7-AMIDO-4-METHYLCOUMARIN
ACETYL-ASP-GLU-VAL-ASP-(AMINO-4-METHYLCOUMARIN)
n-acetyl-asp-glu-val-asp-7-amido-4-methylcoumarin
N-ACETYL-ASP-GLU-VAL-ASP-7-AMINO-4-METHYLCOUMARIN AMC
Caspase 3 Substrate 1m (Apopain), fluorogenic: Ac-DEVD-AMC
Caspase-3 Substrate II, Fluorogenic - CAS 169332-61-0 - Calbiochem
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin >=97% (HPLC), powder
ACETYL-L-ASPARTYL-L-GLUTAMYL-L-VALYL-L-ASPARTIC ACID ALPHA-(4-METHYLCOUMARYL-7-AMIDE)
L-α-Asparagine, N-acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- | [Molecular Formula]
C30H37N5O13 | [MDL Number]
MFCD00671411 | [MOL File]
169332-61-0.mol | [Molecular Weight]
675.64 |
| Chemical Properties | Back Directory | [Boiling point ]
1200.1±65.0 °C(Predicted) | [density ]
1.423±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 10 mM
| [form ]
powder
| [pka]
4.09±0.10(Predicted) | [color ]
white
| [Sequence]
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-Methylcoumarin | [InChIKey]
ALZSTTDFHZHSCA-RNVDEAKXSA-N | [SMILES]
C12C(C)=CC(=O)OC1=CC(NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)C)CC(=O)O)=CC=2 |&1:13,21,28,37,r| |
| Hazard Information | Back Directory | [Description]
Ac-DEVD-AMC is a fluorogenic substrate for caspase-3. Caspase activity can be quantified by fluorescent detection of free AMC (7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. | [Uses]
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin has been used as a substrate for caspase-3 assay in human colon cancer cell line and in bone marrow mesenchymal stem cells. | [Biochem/physiol Actions]
Fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase. | [Excitation / Emission Maximum]
340-360 nm/440-460 nm | [Sequene]
Ac-Asp-Glu-Val-Asp-AMC |
|
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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