| Identification | Back Directory | [Name]
1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)- | [CAS]
169514-76-5 | [Synonyms]
Aza-T-dCyd
5-Aza-4-thio-2-deoxycytidine
1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)- | [Molecular Formula]
C8H12N4O3S | [MOL File]
169514-76-5.mol | [Molecular Weight]
244.27 |
| Chemical Properties | Back Directory | [Boiling point ]
495.4±55.0 °C(Predicted) | [density ]
1.91±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.95±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
2'-Deoxy-4'-thio-5-azacytidine-15N4 is an isotopic labelled compound of 2'-Deoxy-4'-thio-5-azacytidine (D211885). 2'-Deoxy-4'-thio-5-azacytidine is used in the preparation of 5-azacytosine nucleosides with potential anticancer properties. | [in vivo]
5-Aza-4'-thio-2'-deoxycytidine (6.7, 10 mg/kg/day; IP; for 9 days) is effective against NCI-H23 tumor xenografts[1].
5-Aza-4'-thio-2'-deoxycytidine (5 mg/kg/day; IP; for 9 days) decreases DNMT1 levels in tumors of CCRF-CEM tumors mice xenografts[1].
5-Aza-4'-thio-2'-deoxycytidine (1.5 mg/kg; ip; QD×5 rest and repeat 3 cycles) provides modest suppression of tumor growth as well in the HCT116 colon carcinoma, OVCAR3 ovarian tumor xenograft model. 5-Aza-4'-thio-2'-deoxycytidine has minimal antitumor effect in the HL-60 leukemia xenografts[2].
| Animal Model: | Young female athymic nu/nu mice with NCI-H23 tumor fragment[1] | | Dosage: | 6.7 or 10 mg/kg | | Administration: | IP; daily for 9 days | | Result: | Had antitumor efficacy against NCI-H23 tumor xenografts.
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| [IC 50]
DNMT1 |
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