169750-96-3

1196506-86-1

169750-96-3

General procedure for the synthesis of tert-butyl (3-methylpiperidin-3-yl)carbamate from the compound (CAS:1196506-86-1): benzyl 3-((tert-butoxycarbonyl)amino)-3-methylpiperidine-1-carboxylate (78 mg, 0.22 mmol, prepared according to the method described in WO09/140320) was dissolved in EtOH (5 mL) , which was degassed by bubbling N2 (g) into the solution for 10 min. Pd/C (10 wt%, 24 mg, 0.022 mmol) was added. A gas bladder attached to a three-way cork filled with H2 was connected to the flask. The flask was evacuated and backfilled with H2 (repeated 3 times). The mixture was stirred at room temperature for 2 hours. Degassing was again carried out by bubbling N2 (g) into the solution for 10 min, followed by filtration through diatomaceous earth. The filtrate was concentrated to give racemic-tert-butyl (3-methylpiperidin-3-yl) carbamate (42 mg, 0.20 mmol, 88% yield) as a clear, colorless oil.MS (ESI, cationic) m/z: 215.1 (M + 1).