| Identification | Back Directory | [Name]
(2R)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]-3-methylbutanamide:hydrochloride | [CAS]
169799-04-6 | [Synonyms]
(2R)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]-3-methylbutanamide:hydrochloride | [Molecular Formula]
C18H24ClN3O5S | [MOL File]
169799-04-6.mol | [Molecular Weight]
429.918 |
| Hazard Information | Back Directory | [Uses]
CGS 27023A is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A can be used for study of arthritis[1]. | [in vivo]
CGS 27023A (oral gavage, 75 μmol/kg for 10 h) prevents cartilage degradation in stromelysin-induced rabbit cartilage degradation model[1]. | [IC 50]
stromelysins 1: 43 nM (Ki); collagenases 1: 33 nM (Ki); MMP-2: 20 nM (Ki); MMP-9: 8 nM (Ki) | [References]
[1] MacPherson LJ, et al. Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. J Med Chem. 1997;40(16):2525-2532. DOI:10.1021/jm960871c |
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