| Identification | Back Directory | [Name]
Bromoacetamido-PEG8- acid | [CAS]
1698019-89-4 | [Synonyms]
Bromoacetamido-PEG8- acid
Bromoacetamido-PEG8-CH2CH2COOH
1-bromo-2-oxo-6,9,12,15,18,21,24,27-octaoxa-3-azatriacontan-30-oic acid | [Molecular Formula]
C21H40BrNO11 | [MDL Number]
MFCD27635172 | [MOL File]
1698019-89-4.mol | [Molecular Weight]
562.45 |
| Chemical Properties | Back Directory | [Boiling point ]
671.3±55.0 °C(Predicted) | [density ]
1.278±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DCM | [pka]
4.28±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Bromoacetamido-PEG8-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Bromoacetamido-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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