| Hazard Information | Back Directory | [Uses]
WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM[1]. WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2[2]. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively[1]. | [IC 50]
mTOR: 7 nM (IC50); mTORC1; mTORC2; PI3K alpha: 81 nM (IC50); PI3K gamma: 3.11 μM (IC50); CK1 gamma1: 17.8 μM (IC50); p38 alpha: 28.9 μM (IC50) | [storage]
Desiccate at RT | [References]
[1] Yu K, et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 1;69(15):6232-40. DOI:10.1158/0008-5472.CAN-09-0299
[2] Cheng F, et al. Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agent. Biochem Biophys Res Commun. 2016 Feb 5;470(2):324-330. DOI:10.1016/j.bbrc.2016.01.054 |
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BOC Sciences
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16314854226 |
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www.bocsci.com |
| Company Name: |
MedChemExpress
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021-58955995 |
| Website: |
www.medchemexpress.com |
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