| Identification | Back Directory | [Name]
1H-Indole, 3-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]-1-(phenylsulfonyl)- (9CI) | [CAS]
170488-57-0 | [Synonyms]
Tubulin inhibitor 23
1H-Indole, 3-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]-1-(phenylsulfonyl)- (9CI) | [Molecular Formula]
C26H23NO6S | [MOL File]
170488-57-0.mol | [Molecular Weight]
477.53 |
| Hazard Information | Back Directory | [Uses]
Tubulin inhibitor 23 is a potent Tubulin inhibitor with an IC50 of 4.8 μM. Tubulin inhibitor 23 induces cell apoptosis. Tubulin inhibitor 23 shows antiangiogenic activity in a dose-dependent manner. Tubulin inhibitor 23 has the potential for the research of leukaemia[1]. | [in vivo]
Tubulin inhibitor 23 (2, 6 μM; add into embryo water) shows antiangiogenic activity in a dose-dependent manner[1].
Tubulin inhibitor 23 (2, 6 μM; add into embryo water) suppresses the proliferation and metastasis of K562 cells in zebrafish xenografts in a dose-dependent manner[1]. | Animal Model: | 3hpf zebrafish embryos[1] | | Dosage: | 2.0, 6.0 μM | | Administration: | Add into embryo water | | Result: | Decreased the number and length of ISVs (intersegmental vessels) in a dose-dependent inhibition pattern. |
| Animal Model: | Transgenic zebrafish (fil1:EGFP) (K562 cell xenograft)[1] | | Dosage: | 2, 6 μM | | Administration: | Add into embryo water | | Result: | Reduced intensities and decreased tumour area. |
| [References]
[1] Yao Y,wt al. Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors. J Enzyme Inhib Med Chem. 2022 Dec;37(1):652-665. DOI:10.1080/14756366.2022.2032688 |
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