| Identification | Back Directory | [Name]
E4CPG | [CAS]
170846-89-6 | [Synonyms]
E4CPG
(RS)-α-Ethyl-4-carboxyphenylglycine
4-(1-amino-1-carboxypropyl)benzoic acid
(RS)-ALPHA-ETHYL-4-CARBOXYPHENYLGLYCINE
Benzeneacetic acid, α-amino-4-carboxy-α-ethyl- | [Molecular Formula]
C11H13NO4 | [MDL Number]
MFCD01074798 | [MOL File]
170846-89-6.mol | [Molecular Weight]
223.23 |
| Chemical Properties | Back Directory | [Boiling point ]
431.3±40.0 °C(Predicted) | [density ]
1.337±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
H2O : < 0.1 mg/mL (insoluble)DMSO : < 1 mg/mL (insoluble or slightly soluble) | [form ]
Powder | [pka]
1.76±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
E4CPG is a group I/group II metabotropic glutamate receptor antagonist. | [in vivo]
E4CPG (3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.), and 1-10 nmol/site (i.c.v.)) significantly inhibits the nociception induced by the Glutamate-injection (i.pl.; 30 μmol/paw), and the maximal inhibition values for the antinociceptive action of E4CPG in Glutamate-induced nociception are 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.) [4].
E4CPG (35 nM/3.5 μL, i.c.v.) completely blocks long-term depression (LTD) induced by the group I mGluR agonist Dihydroxyphenylglycine (DHPG, 100 nM/5 μL, i.c.v.) in male Sprague-Dawley rats[5]. | Animal Model: | Male Swiss mice (25-35 g)[4] | | Dosage: | 3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.) and 1-10 nmol/ site (i.c.v.)
| | Administration: | Single injection | | Result: | The maximal inhibition values for the antinociceptive action of E4CPG in glutamate-induced
nociception were 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.).
|
| Animal Model: | Male Sprague-Dawley rats[5] | | Dosage: | 35 nM/3.5 μL | | Administration: | Single injection, i.c.v. | | Result: | Completely blocked LTD induced by the group I mGluR agonist dihydroxyphenylglycine (DHPG). |
| [IC 50]
mGluR | [storage]
Room temperature |
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
|