| Hazard Information | Back Directory | [Uses]
Frunevetmab (NV-02) is a felinized anti-nerve growth factor (NGF) monoclonal antibody with a Kd of 20 pM. Frunevetmab can effectively decrease osteoarthritis (OA) pain in cats[1][2]. | [in vivo]
Frunevetmab (1.0-2.8 mg/kg; s.c; on days 0, 28, and 56) shows positive treatment effects in cats with naturally-occurring OA pain and associated mobility impairment and disability[1]. | Animal Model: | Cats with naturally-occurring OA pain and associated mobility impairment and disability[1] | | Dosage: | 1.0-2.8?mg/kg | | Administration: | s.c; 3 times at 28-day intervals; on days 0, 28, and 56 | | Result: | Reliefed the pain from osteoarthritis in cats. |
| [References]
[1] Margaret E Gruen, et al. Frunevetmab, a felinized anti-nerve growth factor monoclonal antibody, for the treatment of pain from osteoarthritis in cats. J Vet Intern Med. 2021 Nov;35(6):2752-2762. DOI:10.1111/jvim.16291
[2] D P Gearing, et al. In Vitro and In Vivo Characterization of a Fully Felinized Therapeutic Anti-Nerve Growth Factor Monoclonal Antibody for the Treatment of Pain in Cats. J Vet Intern Med. 2016 Jul;30(4):1129-37. DOI:10.1111/jvim.13985 |
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Cell Sciences
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