| Identification | Back Directory | [Name]
8-naphthyridine-1(2H)-carboxamide | [CAS]
1708971-55-4 | [Synonyms]
0997
FGF-401
Roblitinib
FGF 401;FGF-401
FGF401( Roblitinib)
Roblitinib（FGF-401）
FGF-401 ISO 9001：2015 REACH
8-naphthyridine-1(2H)-carboxamide
N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide
N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-formyl-6-[(4-methyl-2-oxopiperazin-1-yl)methyl]-3,4-dihydro-2~{H}-1,8-naphthyridine-1-carboxamide
N-[5-Cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-1,8-naphthyridine-1(2H)-carboxamide
1,8-Naphthyridine-1(2H)-carboxamide, N-[5-cyano-4-(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]- | [Molecular Formula]
C25H30N8O4 | [MDL Number]
MFCD31381923 | [MOL File]
1708971-55-4.mol | [Molecular Weight]
506.56 |
| Chemical Properties | Back Directory | [Boiling point ]
852.1±65.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:5.4(Max Conc. mg/mL);10.66(Max Conc. mM)
Chloroform:30.0(Max Conc. mg/mL);59.22(Max Conc. mM) | [form ]
A crystalline solid | [pka]
11.40±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
FGF401 is an inhibitor of FGF receptor 4 (FGFR4; IC50 = 1.9 nM).1 It inhibits proliferation of Huh7 carcinoma cells with an IC50 value of 12 nM. FGF401 induces bile acid synthesis in dogs, increasing plasma and fecal levels of bile acids when administered at a dose of 45 mg/kg per day for four weeks.2 It also decreases serum cholesterol when administered at doses ranging from 5 to 45 mg/kg per day. | [storage]
Store at -20°C |
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