| Identification | Back Directory | [Name]
DONITRIPTAN | [CAS]
170912-52-4 | [Synonyms]
DONITRIPTAN
DONITRIPTANUM
Donitriptan hydrochloride
4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]piperazin-1-yl]benzonitrile
Benzonitrile, 4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]-1-piperazinyl]-
1-[[[3-(2-Aminoethyl)-1H-indol-5-yl]oxy]acetyl]-4-(4-cyanophenyl)-piperazinehydrochloride | [Molecular Formula]
C23H25N5O2 | [MDL Number]
MFCD09832566 | [MOL File]
170912-52-4.mol | [Molecular Weight]
403.48 |
| Chemical Properties | Back Directory | [Boiling point ]
727.1±60.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at RT | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
16.72±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
A novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine. An antimigraine agent. | [Biological Activity]
Brain penetrant 5-HT 1B/1D agonist (pK i values are 9.3 and 9.4 for 5-HT 1D and 5-HT 1B respectively). Inhibits capsaicin-induced external carotid vasodilation and produces selective carotid vasoconstriction in various animal species. Displays antimigraine activity. | [IC 50]
5-HT1B Receptor: 9.4 (pKi); 5-HT1D Receptor: 9.3 (pKi) |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|