| Identification | Back Directory | [Name]
7-AMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER | [CAS]
171049-41-5 | [Synonyms]
2-Boc-7-amino-1,2,3,4-tetrahydroisoquinoline
7-AMINO-2-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE
ethyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate
tert-butyl 7-amino-3,4-dihydro-1H-isoquinoline-2-carboxylate
TERT-BUTYL 7-AMINO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
7-Amino-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline
tert-butyl 7-aMino-1,2,3,4-tetrahydroisoquinoline-2-carboxylate
7-AMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
2(1H)-Isoquinolinecarboxylic acid, 7-amino-3,4-dihydro-, 1,1-dimethylethyl ester | [Molecular Formula]
C14H20N2O2 | [MDL Number]
MFCD04973401 | [MOL File]
171049-41-5.mol | [Molecular Weight]
248.32 |
| Chemical Properties | Back Directory | [Melting point ]
59-61 °C | [Boiling point ]
394.7±42.0 °C(Predicted) | [density ]
1.145±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
4.81±0.20(Predicted) | [Appearance]
Light yellow to light brown Solid |
| Hazard Information | Back Directory | [Synthesis]
A mixed solution of 7-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylic acid tert-butyl ester (33.2) (4.4 g, 15.81 mmol) was stirred with a mixed solution of Pd/C (500 mg, 4.69 mmol) in MeOH (100 mL) for 3 h at room temperature in an H2 atmosphere. Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst. The filtrate was concentrated to afford the target product tert-butyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate (33.3) as a yellow liquid (3.8 g, 96.8% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 1.48 (s, 9H), 2.71 (t, 2H), 3.58 (s, 4H), 4.47 (s, 2H), 6.44 (s, 1H), 6.52 (dd, 1H), 6.91 (d, 1H). | [References]
[1] Patent: WO2016/90079, 2016, A1. Location in patent: Paragraph 00538-00539
[2] Patent: WO2009/158426, 2009, A1. Location in patent: Page/Page column 108-109
[3] Patent: US2015/231142, 2015, A1. Location in patent: Paragraph 0670
[4] Patent: US2011/98311, 2011, A1 |
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