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171094-50-1

171094-50-1 Structure

171094-50-1 Structure
IdentificationBack Directory
[Name]

zanamivir hydrate
[CAS]

171094-50-1
[Synonyms]

ZanaMivir hydrate(5:1)
WKZWSOZFPHGMGO-CQGQYZHTSA-N
D-glycero-D-galacto-Non-2-enonic acid, 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-, hydrate (5:1) (9CI)
[Molecular Formula]

C60H102N20O36
[MOL File]

171094-50-1.mol
[Molecular Weight]

1679.56
Hazard InformationBack Directory
[Uses]

Zanamivir hydrate (5:1) is the hydrate of Zanamivir. Zanamivir is an influenza viral neuraminidase inhibitor with IC50 values of 0.95 nM and 2.7 nM for influenza A and B, respectively[1].
[in vivo]

Zanamivir has a poor bioavailability in oral administration, with only 4-17% of the agent. Oral delivery of Zanamivir has been a problem due to its strong hydrophilic nature that limits its transport across the intestinal epithelium. Permeation enhancers such as sodium cholate, hydroxypropyl β-cyclodextrin could be used with zanamivir to enhance the intestinal permeability[3].

[References]

[1] Gubareva LV, et al. Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates ofinfluenza virus and neuraminidase inhibitor-resistant variants. Antimicrob Agents Chemother. 2001 Dec;45(12):3403-8. DOI:10.1128/AAC.45.12.3403-3408.2001
[2] McKimm-Breschkin JL, et al. Management of influenza virus infections with neuraminidase inhibitors: detection, incidence, and implications of drug resistance. Treat Respir Med. 2005;4(2):107-16. DOI:10.2165/00151829-200504020-00004
[3] Shanmugam S, et al. Zanamivir oral delivery: enhanced plasma and lung bioavailability in rats. Biomol Ther (Seoul). 2013 Mar;21(2):161-9. DOI:10.4062/biomolther.2013.010
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171094-49-8 139110-80-8

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