| Identification | Back Directory | [Name]
3'-O-(t-Butyldimethylsilyl)-2'-O-methyluridine | [CAS]
171268-84-1 | [Synonyms]
3'-O-TBDMS-2'-OME-U
3'-O-TBDMS-2'-OMe-Ur
3'-O-(t-Butyldimethylsilyl)-2'-O-methyluridine
3'-O-(tert-Butyldimethylsilyl)-2'-O-methyluridine
Uridine, 3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-O-methyl-
1-((2R,3R,4R,5R)-4-((tert-Butyldimethylsilyl)oxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | [Molecular Formula]
C16H28N2O6Si | [MDL Number]
MFCD28976151 | [MOL File]
171268-84-1.mol | [Molecular Weight]
372.49 |
| Chemical Properties | Back Directory | [density ]
1.20±0.1 g/cm3(Predicted) | [pka]
9.39±0.10(Predicted) | [InChI]
InChI=1S/C16H28N2O6Si/c1-16(2,3)25(5,6)24-12-10(9-19)23-14(13(12)22-4)18-8-7-11(20)17-15(18)21/h7-8,10,12-14,19H,9H2,1-6H3,(H,17,20,21)/t10-,12-,13-,14-/m1/s1 | [InChIKey]
VWMFRWSCFRRALN-FMKGYKFTSA-N | [SMILES]
OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OC)[C@@H]1O[Si](C(C)(C)C)(C)C |
| Hazard Information | Back Directory | [Uses]
3′-O-[(1,1-Dimethylethyl)dimethylsilyl]-2′-O-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents[1]. | [References]
[1] Connolly GP, et al. Uridine and its nucleotides: biological actions, therapeutic potentials. Trends Pharmacol Sci. 1999 May;20(5):218-25. DOI:10.1016/s0165-6147(99)01298-5 |
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