| Identification | Back Directory | [Name]
Phenol, 3-[[[2-[4-hydroxy-5-methyl-2-(1-methylethyl)phenoxy]ethyl]methylamino]methyl]-4-methoxy-2,5,6-trimethyl- | [CAS]
171277-06-8 | [Synonyms]
JTH-601 free base
JTH 601 free base,JTH601 free base
Phenol, 3-[[[2-[4-hydroxy-5-methyl-2-(1-methylethyl)phenoxy]ethyl]methylamino]methyl]-4-methoxy-2,5,6-trimethyl- | [Molecular Formula]
C24H35NO4 | [MOL File]
171277-06-8.mol | [Molecular Weight]
401.55 |
| Hazard Information | Back Directory | [Uses]
JTH-601 Free base is a novel alpha1-adrenoceptor antagonist that exhibits potent activity in inhibiting phenylephrine-induced contractions in lower urinary tract tissues. JTH-601 Free base competitively antagonizes alpha1-adrenoceptor-mediated contractile responses, demonstrating greater potency than prazosin or tamsulosin. JTH-601 Free base is anticipated to be effective in treating urinary outlet obstruction associated with benign prostatic hyperplasia. | [References]
[1] Effect of JTH-601, a novel alpha1-adrenoceptor antagonist, on the function of lower urinary tract and blood pressure DOI:10.1016/s0014-2999(99)00344-1 |
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