| Identification | Back Directory | [Name]
α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) | [CAS]
171869-93-5 | [Synonyms]
α-Melanocyte-Stimulating Hormone (MSH), amide TFA
α-MSH (human, mouse, rat, porcine, bovine, ovine) trifluoroacetate salt
α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) | [Molecular Formula]
C79H110F3N21O21S | [MOL File]
171869-93-5.mol | [Molecular Weight]
1778.93 |
| Chemical Properties | Back Directory | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMF: 10mg/mL,DMSO: 25mg/mL,DMSO:PBS (pH 7.2) (1:5): 0.16mg/mL | [form ]
A solid | [color ]
White to off-white | [Sequence]
Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
| Hazard Information | Back Directory | [Uses]
α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH TFA is a post-translational derivative of pro-opiomelanocortin (POMC)[1][2]. | [in vivo]
α-MSH TFA (50 μg/0.2 ml saline; i.p.) given systemically effectively modulates inflammatory reactions[3]. | [IC 50]
MC4R | [storage]
Store at -20°C | [References]
[1] Madhuri Singh, et al. C-terminal amino acids of alpha-melanocyte-stimulating hormone are requisite for its antibacterial activity against Staphylococcus aureus. Antimicrob Agents Chemother. 2011 May;55(5):1920-9. DOI:10.1128/AAC.00957-10
[2] 2. M S Kim, et al. Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone. Diabetes. 2000 Feb;49(2):177-82. DOI:10.2337/diabetes.49.2.177
[3] Lipton JM, et al. Mechanisms of antiinflammatory action of alpha-MSH peptides. In vivo and in vitro evidence. Ann N Y Acad Sci. 1999;885:173-182. DOI:10.1111/j.1749-6632.1999.tb08674.x |
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