| Identification | Back Directory | [Name]
N-(3-Hydroxytetradecanoyl)-DL-hoMoserine lactone | [CAS]
172670-99-4 | [Synonyms]
N-(3-oxodecanoyl)-homoserine lactone
3-hydroxy-N-(2-oxooxolan-3-yl)tetradecanamide
N-(3-Hydroxytetradecanoyl)-DL-hoMoserine lactone
3-Hydroxy-N-(tetrahydro-2-oxo-3-furanyl)tetradecanamide
Tetradecanamide, 3-hydroxy-N-(tetrahydro-2-oxo-3-furanyl)-
N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone >=96% (HPLC), carbon 64.7-67.3 % | [Molecular Formula]
C18H33NO4 | [MDL Number]
MFCD16875425 | [MOL File]
172670-99-4.mol | [Molecular Weight]
327.46 |
| Chemical Properties | Back Directory | [Boiling point ]
549.3±50.0 °C(Predicted) | [density ]
1.04±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
Solid | [pka]
14.23±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone (N-(3-oxodecanoyl)-homoserine lactone) is a member of N-Acyl homoserine lactone (AHL) from V. alginolyticus strains. N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone is used for biofilm formation and has antibacterial activity[1]. | [Definition]
ChEBI:3-Hydroxy-N-(2-oxooxolan-3-yl)tetradecanamide is a N-acyl-amino acid. | [Biological Activity]
N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone is a member of N-acyl-homoserine lactone family. N-Acylhomoserine lactones (AHL) regulate gene expression in gram-negative bacteriasuch as Echerichia and Salmonellaand are involved in quorum sensingcell to cell communication among bacteria; for reviews see. Bacterial intercellular communication has become a target for the development of new anti-virulence drugsand a research focus for the prevention of biofilm formation.''Quorum-sensing signal generation | [References]
[1] Liu J, et al. Detection of Diverse N-Acyl-Homoserine Lactones in Vibrio alginolyticus and Regulation of Biofilm Formation by N-(3-Oxodecanoyl) Homoserine Lactone In vitro. Front Microbiol. 2017 Jun 16;8:1097. DOI:10.3389/fmicb.2017.01097 |
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