| Identification | Back Directory | [Name]
Acetic acid, 2-[[3-(2-amino-2-oxoacetyl)-1-([1,1'-biphenyl]-2-ylmethyl)-2-methyl-1H-indol-4-yl]oxy]- | [CAS]
172732-62-6 | [Synonyms]
MeIndoxam
Me-Indoxam
Me Indoxam
Methyl indoxam
Methyl-indoxam
Acetic acid, 2-[[3-(2-amino-2-oxoacetyl)-1-([1,1'-biphenyl]-2-ylmethyl)-2-methyl-1H-indol-4-yl]oxy]- | [Molecular Formula]
C26H22N2O5 | [MOL File]
172732-62-6.mol | [Molecular Weight]
442.46 |
| Hazard Information | Back Directory | [Description]
Me-Indoxam is a sPLA2 inhibitor. It has no effect on arachidonic acid release and platelet activating factor synthesis. | [Uses]
Me-Indoxam is a potent and cell-impermeable secreted phospholipase A2 (sPLA2) inhibitor[1]. | [IC 50]
sPLA2 | [References]
[1] Triggiani M, et al. Lung mast cells are a source of secreted phospholipases A2. J Allergy Clin Immunol. 2009 Sep;124(3):558-65, 565.e1-3. DOI:10.1016/j.jaci.2009.04.035
[2] Granata F, et al. Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor. J Immunol. 2005 Jan 1;174(1):464-74. DOI:10.4049/jimmunol.174.1.464 |
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