| Identification | Back Directory | [Name]
BETA-PHENYL-1,N2-ETHENO-8-BROMOGUANOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT | [CAS]
172806-21-2 | [Synonyms]
Sp-8-Br-PET-cGMPS
SP-8-BR-PET-CGMPS, NA
SP-8-BR-PET-CGMPS SODIUM SALT
8-bromo-beta-phenyl-1,n(2)-ethenoguanosine3’,5’-cyclicmonophosphorothioate
8-bromo-?phenyl-1,n?ethenoguanosine-3’,5’-cyclicmonophosphorothioate,sp-isomer(sp-8-br-pet-cg
BETA-PHENYL-1,N2-ETHENO-8-BROMOGUANOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT
GUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, BETA-PHENYL-1,N2-ETHENO-8-BROMO-, SP-ISOMER, SODIUM SALT | [Molecular Formula]
C18H16BrN5NaO6PS | [MDL Number]
MFCD04037250 | [MOL File]
172806-21-2.mol | [Molecular Weight]
564.28 |
| Hazard Information | Back Directory | [Uses]
Sp-8-Br-PET-cGMPS is a membrane-permeable PKG agonist and a membrane-permeable inhibitor of retinal-type cGMP-gated ion channels, as well as an activator of cGMP-dependent protein kinases I α and I β. Sp-8-Br-PET-cGMPS is resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, has no metabolic side effects, and is more lipophilic and permeable than Sp-8-pCPT-cGMPS. Sp-8-Br-PET-cGMPS can be used to study the role of cGMP signaling pathways in the nervous system[1]. | [References]
[1] Barnstable, Colin J., Ji-Ye Wei, et al. Modulation of synaptic function by cGMP and cGMP-gated cation channels. Neurochemistry international 45.6 (2004): 875-884. DOI:10.1016/j.neuint.2004.03.018 |
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