| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: Slightly soluble,DMSO: Slightly soluble,Ethanol: 12 mg/ml,PBS (pH 7.2): 5 mg/ml | [form ]
A solid | [color ]
white to off-white | [Sequence]
H-Gly-Ile-Gly-Lys-Phe-Leu-Lys-Lys-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Lys-Leu-Leu-Lys-Lys-NH2 |
| Hazard Information | Back Directory | [Uses]
Treatment of diabetic foot ulcer infections (antibacterial). | [Brand name]
Cytolex (Abbott). | [Biological Activity]
Pexiganan (MSI-78) is a 22-aa synthetic cationic antimicrobial peptide (AMP)an analog of magainin found in the African clawed frog (Xenopus laevis). Pexiganan is effective against both Gram-positive (staphylococci MIC ≤16 μg/mLstreptococci & methicillin-resistant S. aureus MIC 8-64 μg/mLS. pyrogenes MIC 16-256 μg/mL) and Gram-negative aerobes (MIC 4-32 μg/mLE. cloacae MCI 1-128 μg/mLA. faecalis 4-64 μg/mL) by disrupting bacteria cell wall or membrane. |
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