| Identification | Back Directory | [Name]
L-Prolinamide, N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-N-(phenylmethyl)-, hydrochloride (1:1) | [CAS]
172837-41-1 | [Synonyms]
Cemadotin hydrochloride
L-Prolinamide, N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-N-(phenylmethyl)-, hydrochloride (1:1) | [Molecular Formula]
C35H57ClN6O5 | [MOL File]
172837-41-1.mol | [Molecular Weight]
677.33 |
| Hazard Information | Back Directory | [Uses]
Cemadotin (LU103793) hydrochloride is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin hydrochloride blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin hydrochloride can be used to research anticancer[1][2]. | [References]
[1] Jordan MA, et al. Suppression of microtubule dynamics by binding of cemadotin to tubulin: possible mechanism for its antitumor action. Biochemistry. 1998 Dec 15;37(50):17571-8. DOI:10.1021/bi9817414
[2] Bernardes GJ, et al. A traceless vascular-targeting antibody-drug conjugate for cancer therapy. Angew Chem Int Ed Engl. 2012 Jan 23;51(4):941-4. DOI:10.1002/anie.201106527 |
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