| Identification | Back Directory | [Name]
5-METHOXY-1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID | [CAS]
17288-36-7 | [Synonyms]
5-Methoxy-6-azaindole-2-carboxylic acid
5-Methoxy-6-azaindole-3-carboxylic acid
5-METHOXY-1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID
1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid, 5-methoxy-
5-Methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid ,98% | [Molecular Formula]
C9H8N2O3 | [MDL Number]
MFCD08448208 | [MOL File]
17288-36-7.mol | [Molecular Weight]
192.17 |
| Chemical Properties | Back Directory | [Boiling point ]
458.4±40.0 °C(Predicted) | [density ]
1.459 | [storage temp. ]
2-8°C | [pka]
3.21±0.30(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Chemical Properties]
White to grey solid | [Synthesis]
GENERAL STEPS: To a stirred solution of ethyl 5-methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylate (1.3 mmol) in ethanol (12 mL) was added 2 M sodium hydroxide solution (1.7 mmol, 1.1 mL). The reaction mixture was heated to reflux for 1 h (for 5-methoxy-1H-pyrrolo[2,3-C]pyridine-2-carboxylic acid) or 2 h (for other derivatives). After completion of the reaction, the solvent was removed by evaporation. Water (10 mL) was added to the residue and the pH was adjusted with acetic acid to 4.0. The precipitate was collected by filtration and the resulting solid was dried in a desiccator to give the target product 5-methoxy-1H-pyrrolo[2,3-C]pyridine-2-carboxylic acid. | [References]
[1] Molecules, 2014, vol. 19, # 9, p. 13342 - 13357 |
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