| Identification | Back Directory | [Name]
H-TYR-PHE-OH | [CAS]
17355-11-2 | [Synonyms]
YF
TYR-PHE
H-TYR-PHE-OH
tyr-phecrystalline
TYR-PHE 99+% CRYSTALLINE
L-TYROSYL-L-PHENYLALANINE
(S)-2-((S)-2-AMino-3-(4-hydroxyphenyl)propanaMido)-3-phenylpropanoic acid | [Molecular Formula]
C18H20N2O4 | [MDL Number]
MFCD00037255 | [MOL File]
17355-11-2.mol | [Molecular Weight]
328.36 |
| Chemical Properties | Back Directory | [Boiling point ]
642.2±55.0 °C(Predicted) | [density ]
1.300±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [form ]
Solid | [pka]
3.40±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells[1][2][3][4]. | [Definition]
ChEBI: Tyr-Phe is a dipeptide formed from L-tyrosine and L-phenylalanine residues. It has a role as a metabolite. | [References]
[1] Zhu Wei, et al. Biomarker containing keratin type II cytoskeleton 1b for differentiating benign thyroid nodules and thyroid cancer: China, CN114264828A[P]. 2022-04-01.
[2] Enari Hiroyuki, et al. Angiotensin converting enzyme (ACE)-inhibiting peptides, ACE inhibitors containing the peptides, their uses, and manufacture of the peptides from shark cartilage: Japan, JP2005154326A[P]. 2005-06-16.
[3] Mao Xiangchao, et al. Method for preparing cod fish peptide with xanthine oxidase inhibitory activity: China, CN113005166A[P]. 2021-06-22.
[4] Hsueh PC, et al. Metabolomic profiling of parapneumonic effusion reveals a regulatory role of dipeptides in interleukin-8 production in neutrophil-like cells. Anal Chim Acta. 2020 Sep 1;1128:238-250. DOI:10.1016/j.aca.2020.06.022 |
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| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
Nextpeptide Inc
|
| Telephone: |
+86-0571-81612335 +8613336028439 |
| Website: |
http://www.nextpeptide.com/ |
|