| Identification | Back Directory | [Name]
3,5-BIS(4-NITROPHENOXY)BENZOIC ACID | [CAS]
173550-33-9 | [Synonyms]
NSC400980
NSC-400980
NSC 400980
3,5-BIS(4-NITROPHENOXY)BENZOIC ACID
3,5-Bis(4-nitrophenoxy)benzoic Acid >
3,5-BIS(4-NITROPHENOXY)BENZOIC ACID 98+% | [Molecular Formula]
C19H12N2O8 | [MDL Number]
MFCD02093450 | [MOL File]
173550-33-9.mol | [Molecular Weight]
396.31 |
| Chemical Properties | Back Directory | [Melting point ]
229.0 to 233.0 °C | [Boiling point ]
577.7±50.0 °C(Predicted) | [density ]
1.485±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
almost transparency in hot DMF | [form ]
powder to crystal | [pka]
3.63±0.10(Predicted) | [color ]
Light orange to Yellow to Green |
| Hazard Information | Back Directory | [Uses]
3,5-Bis(4-nitrophenoxy)benzoic acid is an inhibitor of γ-secretase. 3,5-Bis(4-nitrophenoxy)benzoic acid causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). 3,5-Bis(4-nitrophenoxy)benzoic acid, as a marker for fetal hypothyroidism, is a 3,3’-diiodothyronine sulfate (T2S) cross-reactive material in maternal serum[1]. | [Definition]
ChEBI: 3,5-bis(4-nitrophenoxy)benzoic acid is an aromatic ether. | [Biological Activity]
Inhibitor of γ -secretase; causes a decrease in the released levels of A β 42 and notch-1 A β -like peptide 25 (N β 25). | [References]
[1] Wu SY, et al. Compound W, a 3,3'-diiodothyronine sulfate cross-reactive substance in serum from pregnant women--a potential marker for fetal thyroid function. Pediatr Res. 2007;61(3):307-312. DOI:10.1203/pdr.0b013e318030d17d
[2] Ran Y, et al. Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors. PLoS One. 2015;10(6):e0128619. Published 2015 Jun 5. DOI:10.1371/journal.pone.0128619
[3] Greife A, et al. Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer. 2014;14:628. Published 2014 Aug 29. DOI:10.1186/1471-2407-14-628 |
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