| Identification | Back Directory | [Name]
2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R*(αR*,βS*)]]- (9CI) | [CAS]
173653-47-9 | [Synonyms]
Monomethyl auristatin E intermediate-15
benzyl (2S,3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-hydroxy-2-methylpropanoate
tert-butyl (S)-2-((1R,2S)-3-(benzyloxy)-1-hydroxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate
2-Pyrrolidinepropanoicacid,1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-,phenylmethylester,[2S-[2R*(αR*,βS*)]]-(9CI)
2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R*(αR*,βS*)]]- (9CI) | [Molecular Formula]
C20H29NO5 | [MOL File]
173653-47-9.mol | [Molecular Weight]
363.45 |
| Chemical Properties | Back Directory | [Boiling point ]
492.3±20.0 °C(Predicted) | [density ]
1.156±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [form ]
Oil | [pka]
13.99±0.20(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
Monomethyl auristatin E intermediate-15 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1]. | [References]
[1] Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. DOI:10.1158/0008-5472.CAN-14-1931 |
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