| Identification | Back Directory | [Name]
Pregn-4-ene-3,20-dione, 21-(1,6-dihydro-6-thioxo-9H-purin-9-yl)- | [CAS]
17392-79-9 | [Synonyms]
NSC114792
NSC-114792
NSC 114792
Pregn-4-ene-3,20-dione, 21-(1,6-dihydro-6-thioxo-9H-purin-9-yl)- | [Molecular Formula]
C26H32N4O2S | [MOL File]
17392-79-9.mol | [Molecular Weight]
464.62 |
| Chemical Properties | Back Directory | [Boiling point ]
692.6±65.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 10mg/mL | [form ]
powder | [pka]
8.16±0.20(Predicted) | [color ]
yellow-white | [SMILES]
O=C1CCC2(C)C(CCC3C2CCC4(C)C3CCC4C(CN5C(NC=NC6=S)=C6N=C5)=O)=C1 |
| Hazard Information | Back Directory | [Description]
NSC114792 is a selective inhibitor of JAK3. | [Uses]
NSC114792 is a selective JAK3 inhibitor. NSC114792 induces apoptosis. NSC114792 decreases the protein expression of p-JAK3 and p-STAT5[1]. | [IC 50]
JAK3 | [References]
[1] Kim BH, et al. NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3. Mol Cancer. 2010 Feb 11;9:36. DOI:10.1186/1476-4598-9-36 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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