| Identification | Back Directory | [Name]
HISPOLON(P) | [CAS]
173933-40-9 | [Synonyms]
HISPOLON(P)
(3Z,5E)-6-(3,4-dihydroxyphenyl)-4-hydroxyhexa-3,5-dien-2-one
3,5-Hexadien-2-one, 6-(3,4-dihydroxyphenyl)-4-hydroxy-, (3Z,5E)- | [Molecular Formula]
C12H12O4 | [MDL Number]
MFCD16876372 | [MOL File]
173933-40-9.mol | [Molecular Weight]
220.22 |
| Chemical Properties | Back Directory | [Melting point ]
150.0-151.9 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) | [Boiling point ]
477.2±45.0 °C(Predicted) | [density ]
1.336±0.06 g/cm3(Predicted) | [solubility ]
Acetone: Soluble
Methanol: Soluble | [form ]
Yellow solid. | [pka]
8.35±0.60(Predicted) | [color ]
Light yellow to yellow | [InChI]
InChI=1S/C12H12O4/c1-8(13)6-10(14)4-2-9-3-5-11(15)12(16)7-9/h2-7,14-16H,1H3/b4-2+,10-6- | [InChIKey]
QDVIEIMMEUCFMW-QXYPORFMSA-N | [SMILES]
CC(=O)/C=C(\O)/C=C/C1=CC=C(O)C(O)=C1 |
| Hazard Information | Back Directory | [Uses]
Hispolon, a polyphenol, can be isolated from Phellinus linteus. Hispolon possesses anticancer, antidiabetic, antioxidant, antiviral, hepatoprotective, anti-diabetic, and anti-inflammatory activities[1]. | [in vivo]
Hispolon (2.5-10 mg/kg, i.p.) attenuates LPS-induced acute lung injury in mice[3].
Hispolon (5 and 10 mg/kg, s.c.) reduces tumor growth in DBTRG xenograft mice[4].
| Animal Model: | LPS-induced acute lung injury mice[3] | | Dosage: | 2.5, 5 and 10 mg/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Alleviated the pathological effects in the LPS-challenged mouse.
Reduced the W/D ratio in the lung and MPO activity.
Decreased pro-Inflammatory cytokine production.
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| Animal Model: | DBTRG xenograft mice[4] | | Dosage: | 5 and 10 mg/kg | | Administration: | Subcutaneous injection (s.c.) | | Result: | Reduced tumor volume (RTV).
Inhibited GBM cell proliferation in vivo upon HE and ki-67 staining.
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| [References]
[1] Sarfraz A, et al. Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways. Environ Res. 2020 Nov;190:110017.
[2] Arcella A, et al. Effects of hispolon on glioblastoma cell growth. Environ Toxicol. 2017 Sep;32(9):2113-2123. DOI:10.1002/tox.22419
[3] Huang CY, et al. Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy. Nutrients. 2020 Jun 10;12(6):1742. DOI:10.3390/nu12061742
[4] Liao KF, et al. Hispolon Induces Apoptosis, Suppresses Migration and Invasion of Glioblastoma Cells and Inhibits GBM Xenograft Tumor Growth In Vivo. Molecules. 2021 Jul 26;26(15):4497. DOI:10.3390/molecules26154497 |
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