| Identification | Back Directory | [Name]
Androst-11-ene-14-carboxylic acid,3-(acetyloxy)-4,4,8,12,16-pentamethyl- 15,17,19-trioxo-,methyl ester,(3a,5a,8R,9a,10R,13R)- | [CAS]
174232-42-9 | [Synonyms]
Andrastin A, Aspergillus fumigatus
Androst-11-ene-14-carboxylic acid,3-(acetyloxy)-4,4,8,12,16-pentamethyl- 15,17,19-trioxo-,methyl ester,(3a,5a,8R,9a,10R,13R)-
Androst-11-ene-14-carboxylic acid, 3-(acetyloxy)-4,4,8,12,16-pentamethyl-15,17,19-trioxo-, methyl ester, (3β,5β,8α,9β,10α,13α)- | [Molecular Formula]
C28H38O7 | [MOL File]
174232-42-9.mol | [Molecular Weight]
486.6 |
| Chemical Properties | Back Directory | [Boiling point ]
560.3±50.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | [form ]
A crystalline solid | [pka]
8.84±0.70(Predicted) | [color ]
Off-white | [InChIKey]
GRBXNADBNJGZRK-BCMOVVIDSA-N | [SMILES]
O(C1C(C2[C@@]([C@@H]3C(C4([C@](C(=C3)C)(C(=O)C(C4=O)C)C)C(=O)OC)(CC2)C)(CC1)C=O)(C)C)C(=O)C |
| Hazard Information | Back Directory | [Uses]
Andrastin A is a mycotoxin, PFTase inhibitor, and anticancer compound. | [Biological Activity]
Andrastin A is a meroterpenoid protein farnesyltransferase inhibitor with anticancer activity. It has been shown to inhibit the farnesyltransferase activity of the oncogenic Ras proteins and inhibit the efflux of anticancer drugs from multidrug-resistant cancer cells.''Farnesyltransferase inhibitor with anticancer activity; mycotoxin | [storage]
+4°C |
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| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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