| Identification | Back Directory | [Name]
2-Bromo-5-chlorobenzaldehyde | [CAS]
174265-12-4 | [Synonyms]
2-Bromo-5-chlorobenzalde
2-Bromo-5-chlorobenzaldehyde
5-Chloro-2-bromobenzaldehyde | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C7H4BrClO | [MDL Number]
MFCD00462870 | [MOL File]
174265-12-4.mol | [Molecular Weight]
219.46 |
| Chemical Properties | Back Directory | [Melting point ]
66 °C | [Boiling point ]
258 °C | [density ]
1.698 | [Fp ]
110 °C | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
Crystalline | [color ]
Pale yellow | [InChI]
InChI=1S/C7H4BrClO/c8-7-2-1-6(9)3-5(7)4-10/h1-4H | [InChIKey]
IIISHLMCTDMUHH-UHFFFAOYSA-N | [SMILES]
C(=O)C1=CC(Cl)=CC=C1Br | [CAS DataBase Reference]
174265-12-4 |
| Hazard Information | Back Directory | [Uses]
2-Bromo-5-chlorobenzaldehyde is an important class of pharmaceutical intermediates which can be used in the synthesis of a variety of drugs. 2-Bromo-5-chlorobenzaldehyde can be used in the preparation of the compound 3-chloro-14-cyclohexyl-6-[2-(dimethylamino)ethyl]-7-oxo-5,6,7,8-tetrahydroindolo[2,1-a][2,5]benzo[di-acridine]-11-carboxylic acid, which can be used in the treatment or prevention of viral infections. | [Synthesis]
Step 2: Synthesis of 2-bromo-5-chlorobenzaldehyde; Preparation was carried out with reference to the literature method (J. Am. Chem. Soc. 2002, 124(7), 1354): a mixture of activated powdered 4A molecular sieves (800 mg/mmol of substrate), N-methylmorpholine-N-oxide (2 eq.) and 2-bromomethyl-5-chlorobenzaldehyde (1 eq.) was stirred for 2 hours at 0°C in a N -methylpyrrolidone (0.16 M) were stirred for 2 hours. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the filtrate was subsequently concentrated under vacuum to afford the target product 2-bromo-5-chlorobenzaldehyde in 92% yield. | [References]
[1] Patent: WO2006/46030, 2006, A2. Location in patent: Page/Page column 28
[2] Journal of the American Chemical Society, 2002, vol. 124, # 7, p. 1354 - 1363 |
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