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174575-17-8

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174575-17-8 Structure

174575-17-8 Structure
IdentificationBack Directory
[Name]

SDZ 220-581
[CAS]

174575-17-8
[Synonyms]

SDZ 220-581
(S)-α-Amino-2'-chloro-5-(phosphonomethyl)[1,1'-biphenyl]-3-propanoicacid
alpha-Amino-2'-chloro-5-(phosphonomethyl)(1,1'-biphenyl)-3-propanoic acid
(S)-ALPHA-AMINO-2'-CHLORO-5-(PHOSPHONOMETHYL)[1,1'-BIPHENYL]-3-PROPANOIC ACID
[1,1'-Biphenyl]-3-propanoic acid, α-amino-2'-chloro-5-(phosphonomethyl)-, (αS)-
[Molecular Formula]

C16H17ClNO5P
[MDL Number]

MFCD00948721
[MOL File]

174575-17-8.mol
[Molecular Weight]

369.74
Chemical PropertiesBack Directory
[Boiling point ]

613.3±65.0 °C(Predicted)
[density ]

1.478
[storage temp. ]

Store at RT
[solubility ]

DMSO : 8.57 mg/mL (23.18 mM; Need ultrasonic and warming)
[form ]

Powder
[pka]

1.63±0.10(Predicted)
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H335-H315-H319
[Precautionary statements ]

P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Hazard InformationBack Directory
[Uses]

SDZ 220-581 is a competitive NMDA receptor antagonist.
[Biological Activity]

Competitive NMDA receptor antagonist (pK i = 7.7). Centrally active following oral administration (ED 50 < 3.2 mg/kg for protection against MES-induced seizures).
[in vivo]

SDZ 220-581 (3.2-32 mg/kg; oral administration; for 24 hours; male OF-l mice) treatment dose-dependently protects mice against maximal electroshock seizures (MES). The time-course of protection by SDZ 220-581 is characterized by a rapid onset and long duration of action[1].

Animal Model:Male OF-l mice (18-26 g)[1]
Dosage:3.2 mg/kg, 10 mg/kg, 32 mg/kg
Administration:Oral administration; for 24 hours
Result:Dose-dependently protected mice against maximal electroshock seizures (MES) upon oral administration.
[IC 50]

NMDA Receptor
[storage]

Store at -20°C
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