| Identification | Back Directory | [Name]
S 18986 | [CAS]
175340-20-2 | [Synonyms]
S 18986
(3aS)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide
1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aS)- | [Molecular Formula]
C10H12N2O2S | [MDL Number]
MFCD00952956 | [MOL File]
175340-20-2.mol | [Molecular Weight]
224.28 |
| Chemical Properties | Back Directory | [Boiling point ]
399.9±45.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 50 mM in DMSO | [form ]
Powder | [pka]
9.88±0.20(Predicted) | [color ]
White to light yellow | [InChI]
1S/C10H12N2O2S/c13-15(14)9-5-2-1-4-8(9)12-7-3-6-10(12)11-15/h1-2,4-5,10-11H,3,6-7H2/t10-/m1/s1 | [InChIKey]
MNTIJYGEITVWHU-SNVBAGLBSA-N |
| Hazard Information | Back Directory | [Uses]
S 18986 is a novel cognitive enhancer. | [Biological Activity]
Primary Target
AMPA', 'Reversible: yes | [in vivo]
S 18986 is robust memory-enhancing effects in middle-aged animals compared with aged ones. S 18986 shows antiamnesic properties in middle-aged rodents in spatial memory models [1].
S 18986 (5-50 mg/kg; i.p.) significantly increases both the induction and the maintenance of 4 and 20 bursts tetanus-evoked potentiation[1]. | Animal Model: | Middle-aged (14-15-months-old) mice[1] | | Dosage: | 0.3, 1, and 10 mg/kg | | Administration: | p.o. | | Result: | Showed antiamnesic properties in middle-aged rodents. |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Wuhan Topule
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| Tel: |
+86-02787215551 +86-19945035818 |
| Website: |
http://www.topule.com/ |
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