| Identification | Back Directory | [Name]
1H-Imidazol-2-amine, 5,5'-dithiobis[4-(4-methoxyphenyl)-1-methyl-, dihydrochloride (9CI) | [CAS]
175669-29-1 | [Synonyms]
1H-Imidazol-2-amine, 5,5'-dithiobis[4-(4-methoxyphenyl)-1-methyl-, dihydrochloride (9CI) | [Molecular Formula]
C22H25ClN6O2S2 | [MOL File]
175669-29-1.mol | [Molecular Weight]
505.05 |
| Hazard Information | Back Directory | [Uses]
Polycarpine hydrochloride (1a) is a broad-spectrum Mpro inhibitor (IC50 = 30 nM) that can be isolated from the Polycarpa aurata and also serves as an anti-coronaviral agent. Polycarpine hydrochloride possesses antiviral and antifungal activities, with IC50 values of 30.0 nM and 0.12 μM against SARS-CoV-2 Mpro and PEDV Mpro, respectively[1]. | [References]
[1] Zhang J, et al. An ascidian Polycarpa aurata-derived pan-inhibitor against coronaviruses targeting Mpro. Bioorg Med Chem Lett. 2024;103:129706. DOI:10.1016/j.bmcl.2024.129706 |
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