| Identification | Back Directory | [Name]
PALMITOYL COENZYME A POTASSIUM SALT | [CAS]
1763-10-6 | [Synonyms]
Palmityl-CoA
PALMITOYL-COA
Palmityl coenzyme A
Palmitoyl Coenzyme A
S-palmitoylcoenzyme A
Coenzyme A S-palmitate
Coenzyme A S-hexadecanoate
PALMITOYL COENZYME A, K SALT
coenzyme A palmitoyl derivative
PALMITOYL COENZYME A POTASSIUM SALT
N-HEXADECANOYL COENZYME A, POTASSIUM
N-HEXADECANOYL COENZYME A POTASSIUM SALT
Palmitoyl coenzyme A potassium salt≥ 88% (TLC)
PALMITOYL COENZYME A POTASSIUM SALT(1763-10-6)
Adenosine 3'-phosphoric acid 5'-[diphosphoric acid β-[(R)-3-hydroxy-4-[[3-[[2-(hexadecanoylthio)ethyl]amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutyl]] ester
[5-(6-aminopurin-9-yl)-2-[[[[3-[2-(2-hexadecanoylsulfanylethylcarbamoyl)ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propoxy]-hydroxy-phosphoryl]oxy-hydroxy -phosphoryl]oxymethyl]-4-hydroxy-oxolan-3-yl]oxyphosphonic acid | [EINECS(EC#)]
217-177-7 | [Molecular Formula]
C37H66N7O17P3S | [MDL Number]
MFCD02259056 | [MOL File]
1763-10-6.mol | [Molecular Weight]
1005.94 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Definition]
ChEBI: Palmitoyl-CoA is a long-chain fatty acyl-CoA resulting from the formal condensation of the carboxy group of hexadecanoic acid with the thiol group of coenzyme A. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a long-chain fatty acyl-CoA, a palmitoyl bioconjugate, an 11,12-saturated fatty acyl-CoA and a 3-substituted propionyl-CoA. It is functionally related to a coenzyme A, a hexadecanoic acid and a hexadecanoate. It is a conjugate acid of a palmitoyl-CoA(4-). | [Purification Methods]
Possible impurities are palmitic acid, S-palmitoyl thioglycolic acid and S-palmitoyl glutathione. These are removed by placing ca 200mg in a centrifuge tube and extracting with Me2CO (20mL), followed by two successive extractions with Et2O (15mL) to remove S-palmitoyl thioglycolic acid and palmitic acid. The residue is dissolved in H2O (4 x 4 mL), adjusted to pH 5 and centrifuged to remove insoluble S-palmitoyl glutathione and other insoluble impurities. To the clear supernatant is added 5% HClO4 (6mL) whereby S-palmitoyl CoA precipitates. The precipitate is washed with 0.8% HClO4 (10mL) and finally with Me2CO (3x 5mL) and dried in vacuo. It is stable for at least one year in dry form at 0o in a desiccator (dark). Solutions are stable for several months at -15o. Its solubility in H2O is 4%. The adenine content is used as the basis of purity with max at 260 and 232nm ( 6.4 x 106 and 9.4 x 106 cm2/mol, respectively). Higher absorption at 232nm would indicate other thio ester impurities, e.g. S-palmitoyl glutathione, which absorb highly at this wavelength. Also the phosphate content should be determined, and acid phosphate can be titrated potentiometrically. [Seubert Biochemical Preparations 7 80 1960, Srer et al. Biochim Biophys Acta 33 31 1959, Kornberg & Pricer J Biol Chem 204 329 , 345 1953, Beilstein 26 III/IV 3665.] |
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BOC Sciences
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Creative Enzymes
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www.creative-enzymes.com |
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