| Identification | Back Directory | [Name]
(R)-1-(3-Bromophenyl)ethylamine | [CAS]
176707-77-0 | [Synonyms]
Albb-005066
(R)-3-Bromo-α
?-1-(3-Bromophenyl)ethanamine
(R)-3-Bromo-α-methylbenzylamine
(R)-1-(3-BROMOPHENYL)ETHANAMINE
(R)-1-(3-BROMOPHENYL)ETHYLAMINE
[(1R)-1-(3-Bromophenyl)ethyl]amine
(R)-1-(3-bromophenyl)ethan-1-amine
(R)-3-BROMO-ALPHA-METHYLBENZYLAMINE
(R)-(+)-3-BROMO A-METHYLBENZYLAMINE
(R)-3-BroMo-α-MethylbenzylaMine
Benzenemethanamine, 3-bromo-α-methyl-, (αR)-
(1R)-1-(3-bromophenyl)ethanamine(SALTDATA: FREE)
(R)-1-(3-Bromophenyl)ethylamine, ChiPros 99%, ee 98+%
Benzenemethanamine, 3-bromo-.alpha.-methyl-, (.alpha.R)-
(R)-1-(3-BroMophenyl)ethylaMine, ChiPros|r, 99%, ee 98+% | [Molecular Formula]
C8H10BrN | [MDL Number]
MFCD00671637 | [MOL File]
176707-77-0.mol | [Molecular Weight]
200.08 |
| Chemical Properties | Back Directory | [Boiling point ]
96°C/4mm | [density ]
1.33 | [Fp ]
96°C/4mm | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
8.73±0.10(Predicted) | [Appearance]
Colorless to light yellow Liquid | [Optical Rotation]
Consistent with structure | [Sensitive ]
Air Sensitive |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of (R)-1-(3-bromophenyl)ethylamine from 1-(3-bromophenyl)ethanone oxime is as follows: 1 equiv. of N-[1-(3-bromophenyl)ethylidene]hydroxylamine, 5 mol% of RuCl(Cymene)(S-tol-Binap)Cl catalyst, 5 equiv. of additives, and 70 vol. of methanol (relative to the amount of the oxime) are added to a glass vial. The glass vials were placed in a parallel autoclave, which was pressurized to 30 bar with hydrogen, then heated to 90 °C and kept for 24 hours. After completion of the reaction, the system was cooled to 20 °C. The reaction mixture was diluted with isopropyl alcohol. The reaction mixture was diluted with isopropanol and analyzed by chiral HPLC. | [References]
[1] Patent: WO2015/178847, 2015, A1. Location in patent: Page/Page column 7-8 |
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