| Identification | Back Directory | [Name]
NEORUSCOGENIN | [CAS]
17676-33-4 | [Synonyms]
NEORUSCOGENIN
Einecs 241-660-1
spirost-5,25(27)-dien-1β,3β-diol
spirost-5,25(27)-dien-1β,3β-diol
Spirosta-5,25(27)-diene-1β,3β-diol
SPIROSTA-5,25(27)-DIENE-1B,3B-DIOL
spirosta-5,25(27)-diene-1beta,3beta-diol
Spirosta-5,25(27)-diene-1,3-diol,(1b,3b)-
Spirosta-5,25(27)-diene-1,3-diol, (1β,3β)-
Spirosta-5,25(27)-diene-1,3-diol, (1.beta.,3.beta.)-
Neoruscogenin, 98%, from Ophiopogon japonicus (Linn. f.) Ker-Gawl. | [EINECS(EC#)]
241-660-1 | [Molecular Formula]
C27H40O4 | [MDL Number]
MFCD00210534 | [MOL File]
17676-33-4.mol | [Molecular Weight]
428.6 |
| Chemical Properties | Back Directory | [Melting point ]
196～198℃ | [Boiling point ]
566.6±50.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
4°C, protect from light | [solubility ]
≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide | [form ]
crystalline solid | [pka]
14.55±0.70(Predicted) | [color ]
White to off-white | [Major Application]
food and beverages | [Cosmetics Ingredients Functions]
SKIN CONDITIONING | [InChI]
1S/C27H40O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,16,18-24,28-29H,1,6-14H2,2-4H3 | [InChIKey]
ALTRINCJVPIQNK-UHFFFAOYSA-N | [SMILES]
O1C6(OCC(=C)CC6)C(C2C1CC3C2(CCC4C3CC=C5C4(C(CC(C5)O)O)C)C)C | [LogP]
4.210 (est) |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [HS Code ]
29329990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Chemical Properties]
White needle-shaped crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the Ruscus aconitifolia. | [Uses]
Neoruscogenin is a natural sapogenin isolated from Butcher’s broom (R. rhizoma), which is traditionally used against chronic venous disorders. | [Biological Activity]
neoruscogenin is a bioavailable, potent, and high-affinity agonist of the nuclear receptor rorα [1]. neoruscogenin is a natural sapogenin extracted from butcher’s broom (rusci rhizoma, ruscus aculeatus, ruscaceae) [2].rar-related orphan receptor alpha (rorα) is a nuclear receptor that participates in the transcriptional regulation of some genes involved incircadian rhythm. genetic studies have revealed that rorα plays an important role in the development of the central nervous system and has been associated with genetic lesions in mice [3]. | [in vitro]
in confluent human microvascular endothelial cells (hmec-1), pre-treatment with neoruscogenin slightly decreased the permeability at concentrations up to 100 μm (71.8%). the ec50 of neoruscogenin against the nuclear receptor rorα was 110 nm [1]. | [in vivo]
in mice, oral administration of neoruscogenin (3 mg/kg/d) for seven days up-regulated the expression of several rorα-inducible genes in the liver [1]. | [References]
[1] helleboid s, haug c, lamottke k, et al. the identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor rorα (nr1f1)[j]. journal of biomolecular screening, 2013: 1087057113497095.
[2] barbi m, willer e a, rothenhfer m, et al. spirostanol saponins and esculin from rusci rhizoma reduce the thrombin-induced hyperpermeability of endothelial cells[j]. phytochemistry, 2013, 90: 106-113.
[3] giguère v. orphan nuclear receptors: from gene to function 1[j]. endocrine reviews, 1999, 20(5): 689-725. |
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| Company Name: |
WG reagent
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| Telephone: |
13391486464 |
| Website: |
www.wgchemical.com |
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