| Identification | Back Directory | [Name]
L-a-Lecithin-diarachidonoyl | [CAS]
17688-29-8 | [Synonyms]
20:4 (Cis) PC
L-a-DiarachidonoylLecithin
L-a-Lecithin-diarachidonoyl
1,2-Diarachidonoyl-sn-glycero-3-PC
β,γ-diarachidoyl-L-α-phosphatidylcholine
1,2-diarachidonoyl-glycero-3-phosphocholine
1,2-di-O-arachidonoyl-sn-glycero-3-phosphocholine | [Molecular Formula]
C48H80NO8P | [MDL Number]
MFCD00171670 | [MOL File]
17688-29-8.mol | [Molecular Weight]
830.14 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Ethanol: 25 mg/ml | [form ]
Liquid | [color ]
Colorless to light yellow | [InChIKey]
LZLVZIFMYXDKCN-HLKGGLNDSA-N | [SMILES]
[P](=O)([O-])(OC[C@H](OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C\CCCCC)COC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC)OCC[N+](C)(C)C |
| Hazard Information | Back Directory | [Description]
1,2-Diarachidonoyl-sn-glycero-3-PC is a phospholipid containing the polyunsaturated long-chain (20:4) arachidonic acid inserted at the sn-1 and sn-2 positions. It can be used in the generation of micelles, liposomes, and other types of artificial membranes. | [Uses]
L-?a-?Lecithin-?diarachidonoyl is used in the preparation of compounds and lipid nanoparticle compounds for intracellular delivery of therapeutic agents. | [Definition]
ChEBI: A 1,2-diacyl-sn-glycero-3-phosphocholine in which the phosphatidyl acyl groups at positions 1 and 2 are both arachidonoyl. | [References]
[1] SCHWIEGER C, ACHILLES A, SCHOLZ S, et al. Binding of amphiphilic and triphilic block copolymers to lipid model membranes: the role of perfluorinated moieties[J]. Soft Matter, 2014, 33: 6147-6160. DOI: 10.1039/c4sm00830h
[2] MATHEUS MALTA DE Sá. Understanding Miltefosine–Membrane Interactions Using Molecular Dynamics Simulations[J]. Langmuir, 2015, 31 15: 4503-4512. DOI: 10.1021/acs.langmuir.5b00178 |
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