| Identification | Back Directory | [Name]
6-methoxy-2-phenyl-tetralone | [CAS]
1769-84-2 | [Synonyms]
6-Methoxy-2-phenyltetralone
6-Methoxy-2-phenyl-1-tetralone
6-Methoxy-2-phenylnaphthalen-1(4H)-one
6-Methoxy-2-phenyl-3,4-dihydronaphthalen-1(2H)
6-methoxy-2-phenyl-3,4-dihydro-2H-naphthalen-1-one
3,4-dihydro-6-methoxy-2-phenyl-1(2H)-Naphthalenone
6-Methoxy-2-phenyl-3,4-dihydronaphthalen-1(2H)-one
1(2H)-Naphthalenone, 3,4-dihydro-6-methoxy-2-phenyl-
6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-one | [Molecular Formula]
C17H16O2 | [MDL Number]
MFCD10698841 | [MOL File]
1769-84-2.mol | [Molecular Weight]
252.31 |
| Chemical Properties | Back Directory | [Melting point ]
113-116 °C | [Boiling point ]
429.9±45.0 °C(Predicted) | [density ]
1.141±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
powder | [color ]
Yellow |
| Hazard Information | Back Directory | [Synthesis]
A Schlenk flask was charged with 6-methoxy-3,4-dihydronaphthalen-1(2H)-one (1,352 mg, 2.0 mmol), sodium tert-butanolate (365 mg, 3.8 mmol) and Pd-132 (1.4 mg, 0.002 mmol). The flask was sealed with a rubber stopper, evacuated three times and backfilled with nitrogen operation. Chlorobenzene (0.20 mL, 2.0 mmol) was added to the flask via a gas-tight syringe, followed by dioxane (2.0 mL). The reaction mixture was stirred at 100°C for 18 hours. After completion of the reaction, the mixture was filtered through a silica gel column and the silica gel pad was washed with methyl tert-butyl ether (MTBE, 20 mL). The filtrate was concentrated to give the off-white solid product 6-methoxy-2-phenyltetralone (455 mg, 90% yield). The structure of the product was confirmed by 1H NMR (CDCl3) and 13C NMR (CDCl3). | [References]
[1] Chemistry - A European Journal, 2014, vol. 20, # 52, p. 17272 - 17276
[2] Patent: WO2012/159981, 2012, A2. Location in patent: Page/Page column 20
[3] Organic and Biomolecular Chemistry, 2015, vol. 13, # 34, p. 9012 - 9021 |
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SynAsst Chemical.
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